Ovariectomy Reduces Ischemic Tolerance in Aged but not Adult Rat Myocardium
نویسندگان
چکیده
منابع مشابه
Effect of Ischemic Conditioning on Some Motor and Cognitive Factors in the Ovariectomy-Induced Aged Rats
Introduction: During menopause, which is a part of the aging process in women, the level of sex hormones decreases, which causes problems such as memory impairment and cognitive functions. One of the treatment options for these disorders is hormone therapy, which has several side effects. The present study investigated the effect of remote ischemic conditioning (RIC) technique on memory improve...
متن کاملOvarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance.
Although research suggests that ovariectomy (ovx) is detrimental to spatial cognition in young rats, little work has evaluated the cognitive effects of ovx in aged rats. The authors investigated the effects of ovx in aged rats using the water radial-arm maze. In Study 1, young rats and aged rats receiving ovx 1.5 months before testing outperformed aged rats receiving sham surgery or ovx 21 days...
متن کاملPKC Activation Protects the Cardiomyocytes from Ischemic Insult in Adult, but not in Neonatal Rat Heart
Background and Objectives:Protein kinase C (PKC) has been known to play a central role in mediating ischemic preconditioning. The isoform of the PKC changes during the development of the heart in rats. Therefore, the protective effects of PKC activation may vary between neonatal and adult hearts. Materials and Methods: To test this hypothesis, primary cultures of neonatal and adult rat ventricu...
متن کاملChronic developmental lead exposure reduces neurogenesis in adult rat hippocampus but does not impair spatial learning.
The dentate granule cell (DG) layer of the hippocampal formation has the distinctive property of ongoing neurogenesis that continues throughout adult life. Although the function of these newly generated neurons and the mechanisms that control their birth are unknown, age, activity, diet and psychosocial stress have all been demonstrated to regulate this type of neurogenesis. Little information ...
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Background: Pentoxifylline (PTX) is used in human for intermittent claudication and cerebral vascular disorders including cerebrovascular dementia. It also inhibits the synthesis of tumor necrosis factor-α (TNF-α), which is believed to be neurotoxic in animal models of cerebral ischemia. The objective of this study was to examine the role of PTX on ischemia/reperfusion injures in rat model of t...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a1156